New generation vaccines take advantage of NGS
The genome era fostered by Next Generation Sequencing has started a new revolution in vaccine development.
Thanks to the massive sequencing technologies we know the sequences of multiple isolates of the most important pathogens. It allows us to select, for example, the set of membrane proteins or the secreted proteins of the different isolates of a pathogen. Thus, genomic information has been successfully used for the identification of novel protein antigens to develop vaccines against various human pathogens.
The concept of reverse vaccinology was applied for the first time to serogroup B of Neisseria meningitidis (MenB).
The availability of genome sequences for the different isolates of a single species enables quantitative analyses of their genomic diversity through comparative genomic analyses.
We offer a complete service for the design and the use of Next Generation Sequencing in vaccine development projects.