The Project CARDIOBIOME , ITC-20151148 , is focused in developing a bioinformatics platform integrated with the Electronic Health Record for human microbiome analysis. AMI (Acute Myocardial Infarction will be taken as a proof of concept
The ministry of Industry through their Agency CDTI has granted $1 M to the consortium CARDIOBIOME in which Era7 Bioinformatics has the task of developing a cloud based bioinformatics platform for the analysis of 16S data from human microbiomes and for facilitating the integration with EHR (Electronic Health Record) following standards like HL7, FHIR and SMART.
The Project will be focused on Acute Myocardial Infarction as proof of concept and more than 4000 samples from patients will be sequenced.
This new research and development project will be a new impulse for getting our goal: to be an international reference for 16S metagenomics, especially for microbiome projects.
The general interest in getting genomics data integrated with health care pipelines and EHR should be complemented with the integration of 16S metagenomics results since these results will be very important as useful biomarkers for prevention, diagnosis and follow-up of many diseases. In Era7, we are convinced that Precision Medicine will incorporate in the EHR 16S data from different microbiomes: oral, gut, blood, skin, bronchial or from disease-specific regions as tumors or abscesses.”
Declared Dr. Eduardo Pareja, CEO of Era7 Bioinformatics.
Microbiome analysis is an exponentially growing application of NGS not only for human health studies but also for sectors such as animal and plant health, industry, biofuel or agrifood.
In addition to this $430 K grant, very recently, Era7 was awarded with another grant for 16S metagenomics research
BIG4: A global network to study the "big 4" insect groups
BIG4 is an ITN European Union project. It is a global network to amalgamate the cutting edge methods of genomics, phylogenetics, informatics, taxonomy, semantic biodiversity publishing and citizen science, into the highly competitive cross-disciplinary training program for 15 ESRs with a stronghold in biosystematics and with the wide scope of complementary skills transferrable to other science disciplines, business, or industry. These 15 future leaders will extend the exploration of the four biggest groups of living organisms in a more forward looking way than has been attempted before.
The urgent focus on the “big four” insect groups, i.e. Coleoptera (beetles), Hymenoptera (wasps, ants and bees), Diptera (flies and mosquitoes), and Lepidoptera (butterflies and moths) is justified by the super abundance of this form of Life, and by the growing need by science and society to make better use of the enormous potential hidden in their biological diversity.
BIG4 aims  to gain a robust systematic knowledge that explains the evolutionary origin, diversification, past and present distributions of living organisms,  to model their future dispersal and  to predict the traits of species that are yet unknown.
Additionally, BIG4 strives for  implementing organismal features into engineering, medicine, agricultural or environmental solutions, the insect flight mechanics and more effective pollination to mention just a few. Such knowledge is in a particularly high demand in respect of the four biggest insects groups comprising the most important model organisms, the most dangerous pests or disease vectors, the most abundant invasive species and the most fragile entire species communities undergoing extinction due to habitat destruction. By integrating academia with the business and public sectors, BIG4 will greatly increase services and beneficial products provided by the biosystematics as a science. BIG4 will place insect mega-diversity as a powerful service for economic and societal needs such as environmental monitoring, biological control, biomedicine, or ecological farming. Above all, the BIG4-trained 15 ESRs will promote a truly holistic understanding of Life by science, and its appreciation by society for the sake of safeguarding and sustainable use of Earth biosphere.
NEXTmicro: A bioinformatics platform designed to manage NGS outbreak data
This project is funded in part by the Spanish CDTI (Centro para el Desarrollo Tecnológico Industrial) and is being and will be developed during 2012 and 2013.
The goal of the project is the development of a platform able to manage all the NGS sequence data and related data important in an outbreak.
The NEXTMICRO project includes the incorporation to the platform of BG7 annotation system (See publication about BG7 in PLOS ONE) and new Cloud Computing pipelines and services specially designed or adapted to manage NGS outbreak data from hospital and community outbreaks.
This platform will improve our services for hospitals and healthcare institutions and will allow us to provide:
- Help in the design of the specific sequencing strategy
- Sequencing services
- Assembly and Functional rich Annotation based on BG7
- Cloud storage and management of the data
- Clinical environment adapted reports
- Help in the design of molecular diagnostic methods (MLST, PCR)
- Follow-up of the outbreak and sequencing of new related isolates if needed
INTERCROSSING: An ITN European project about Next Generation Sequencing, Cloud Computing and Population Genetics
The INTERCROSSING project is an ITN European Union project. In this project 13 Early Stage Researchers will learn about NGS, Cloud Computing and Population Genetics by means of the developing of a research project. Era7 Bioinformatics participates in this project hosting two ESRs that will work in new mathematical approaches for NGS data management using Cloud Computing.
The INTERCROSSING project started in 2012 and will last until 2015.
ONCOEXPERT: Aiming to provide a better diagnostics and a better theraupetic focus on cancer treatment
This project aims to develop a tool to help the healthcare professional provide a better diagnostics and a better therapeutic focus on cancer treatment, and for this universal process to helps elaborate some medical guidelines to be implanted in any healthcare center. It is based on getting a prioritized evaluation of the huge amount of clinical and molecular data that can be generated for a specific patient, that could be applied in any environment and that allows avoiding unnecessary therapies, for any type of cancer.
The precise and individualized diagnostics is still a challenge when treating the oncological patient. Very similar tumors in histopathology and clinical stage might respond to the same therapy in very different ways, so it is necessary to take into account all the variables of the patient, like molecular and genetic markers, etc. On the other hand, the existing treatments are still sub-optimal.
The progress made in the last 20 years in the field of cancer biology and the design of new drugs let us contemplate the practice of an individualized, or personalized, medicine to treat those patients who suffer from tumors with identified therapeutical targets.
BRACHVAC: Development of a global vaccine against Brachyspira
This project is carried out by a Consortium in which Era7 Bioinformatics is a partner. The Consortium is funded by the INNPACTO Program of the Ministerio de Economia y Competitividad.
The project goal is the development of a global vaccine against Brachyspira hyodysenteriae and Brachyspira pilosicoli by means of a bacterial genomics, proteomics and recombinant proteins production. Era7 bioinformatics task is the analysis of near one hundred bacterial genomes.