Era7 Bionformatics research team finds bacterial 16S rRNA in 99 out of 99 Ebola samples in a public dataset

02/10/2016

 

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Era7 Bioinformatics’ research team has analyzed 99 RNA-Seq Ebola patient serum samples from a public dataset looking for 16S bacterial sequences. This work was guided by the similarity of the clinical manifestations in Ebola disease and in sepsis and by the idea that it could be related to the reported bacterial translocation from gut to blood provoked by some viruses. To check the presence of translocated bacteria in serum from Ebola patients, the team analyzed 99 RNA-seq Ebola patient samples from a public dataset  (Science 2014; 345(6202): 1369-1372) looking for 16S bacterial sequences. The result of this analysis was the detection of bacterial 16S sequences in all the 99 analyzed serum samples from Ebola patients.

“In Era7 Bioinformatics we are specialists in obtaining more from the data. I am very proud of our team because they have been able to uncover important information from a dataset used to describe and analyze the Ebola virus genomes of the last outbreak. We worked with data from an experiment that was designed to answer other questions. Sometimes NGS data can provide not only the information you are looking for, but also other new relevant information. The fact that all the infected patients from this study show bacterial 16S RNA in their blood is, to our knowledge, completely new and would serve to make further studies regarding Ebola infection pathogenesis and treatment" says Eduardo Pareja, CEO of Era7. This work constitutes an example of the power of bioinformatics to analyze already existing NGS data from previous research.” declared Dr. Eduardo Pareja, CEO of Era7. “It is amazing how Next Generation Sequencing and Bioinformatics are revolutionizing Biology, Medicine and Biotechnology” added Eduardo Pareja.

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